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2S50
Mechanism of action Elamipretide (SS-31) is a mitochondrially-targeted peptide that binds to the adenine nucleotide translocator (ANT) and ATP synthase. It improves ADP sensitivity in aged mitochondria by increasing ADP uptake via ANT, resulting in increased ATP production. The peptide also decreases protein S-glutathionylation and mitochondrial free radical production, suggesting antioxidant effects. Its mechanism relies on membrane interactions and modifications of inner mitochondrial membrane electrostatics. Research applications • Mitochondrial function and ADP sensitivity in aged tissues • Oxidative stress and S-glutathionylation • Aging and mitochondrial dysfunction models • Muscle force and systolic cardiac function in aged animals • Age-related diseases Biological properties studied • Mitochondrial targeting via ANT and ATP synthase • Improved ATP production and ADP response • Reduced ROS and antioxidant effects • Potential restoration of mitochondrial function with age • Purity: ≥99% (HPLC) • Presentation: Lyophilized powder 50 mg • Storage: 2-8°C • Recommended diluent: Bacteriostatic water (BA) Research use only.
220,00 €
2S30
Mechanism of action Elamipretide (SS-31) is a mitochondrially-targeted peptide that binds to the adenine nucleotide translocator (ANT) and ATP synthase. It improves ADP sensitivity in aged mitochondria by increasing ADP uptake via ANT, resulting in increased ATP production. The peptide also decreases protein S-glutathionylation and mitochondrial free radical production, suggesting antioxidant effects. Its mechanism relies on membrane interactions and modifications of inner mitochondrial membrane electrostatics. Research applications • Mitochondrial function and ADP sensitivity in aged tissues • Oxidative stress and S-glutathionylation • Aging and mitochondrial dysfunction models • Muscle force and systolic cardiac function in aged animals • Age-related diseases Biological properties studied • Mitochondrial targeting via ANT and ATP synthase • Improved ATP production and ADP response • Reduced ROS and antioxidant effects • Potential restoration of mitochondrial function with age • Purity: ≥99% (HPLC) • Presentation: Lyophilized powder 30 mg • Storage: 2-8°C • Recommended diluent: Bacteriostatic water (BA) Research use only.
150,00 €
2S10
Mechanism of action Elamipretide (SS-31) is a mitochondrially-targeted peptide that binds to the adenine nucleotide translocator (ANT) and ATP synthase. It improves ADP sensitivity in aged mitochondria by increasing ADP uptake via ANT, resulting in increased ATP production. The peptide also decreases protein S-glutathionylation and mitochondrial free radical production, suggesting antioxidant effects. Its mechanism relies on membrane interactions and modifications of inner mitochondrial membrane electrostatics. Research applications • Mitochondrial function and ADP sensitivity in aged tissues • Oxidative stress and S-glutathionylation • Aging and mitochondrial dysfunction models • Muscle force and systolic cardiac function in aged animals • Age-related diseases Biological properties studied • Mitochondrial targeting via ANT and ATP synthase • Improved ATP production and ADP response • Reduced ROS and antioxidant effects • Potential restoration of mitochondrial function with age • Purity: ≥99% (HPLC) • Presentation: Lyophilized powder • Storage: 2-8°C • Recommended diluent: Bacteriostatic water (BA) Research use only.
85,00 €
