Mechanism of action
Elamipretide (SS-31) is a mitochondrially-targeted peptide that binds to the adenine nucleotide translocator (ANT) and ATP synthase. It improves ADP sensitivity in aged mitochondria by increasing ADP uptake via ANT, resulting in increased ATP production. The peptide also decreases protein S-glutathionylation and mitochondrial free radical production, suggesting antioxidant effects. Its mechanism relies on membrane interactions and modifications of inner mitochondrial membrane electrostatics.
Research applications
• Mitochondrial function and ADP sensitivity in aged tissues
• Oxidative stress and S-glutathionylation
• Aging and mitochondrial dysfunction models
• Muscle force and systolic cardiac function in aged animals
• Age-related diseases
Biological properties studied
• Mitochondrial targeting via ANT and ATP synthase
• Improved ATP production and ADP response
• Reduced ROS and antioxidant effects
• Potential restoration of mitochondrial function with age
• Purity: ≥99% (HPLC)
• Presentation: Lyophilized powder
• Storage: 2-8°C
• Recommended diluent: Bacteriostatic water (BA)
Research use only.
