Mechanism of action
TB-500 is the synthetic form of Thymosin β4 (Tβ4), a 43-amino acid peptide. Its primary mechanism involves sequestration of G-actin, regulating actin polymerization that drives cell migration and proliferation. The peptide promotes angiogenesis (formation of new vessels) via surface receptor binding and internalization. Distinct active fragments have been identified: anti-inflammatory (amino acids 1-4), anti-apoptotic and cytoprotective (1-15), cell migration stimulation (17-23).
Research applications
• Wound healing: accelerated reepithelialization, collagen deposition, wound contraction, angiogenesis in preclinical models
• Keratinocyte and endothelial cell migration
• Tendons and ligaments: tissue repair and flexibility
• Inflammation and cell regeneration
Biological properties studied
• Actin regulation and cell migration
• Promotion of angiogenesis and healing
• Anti-inflammatory and cytoprotective effects
• Potential synergy with BPC-157 for tendon healing
• Stimulation of fibroblast proliferation
Preparation and storage
Reconstitute with bacteriostatic water; inject diluent along vial wall without shaking. Never mix one peptide with another in the same syringe. Reconstituted solution stored ~21 days refrigerated (2-8°C).
• Purity: ≥99% (HPLC)
• Presentation: Lyophilized powder
• Storage: 2-8°C
• Recommended diluent: Bacteriostatic water (BA)
Research use only.
