Mechanism of action
BPC-157 interacts with the nitric oxide (NO) pathway to regulate vascular function and stimulate key growth factors. The NO-mediated healing mechanism involves accelerated angiogenesis—formation of new blood vessels—enabling increased delivery of oxygen and energy to the damaged site. The peptide stimulates production of angiogenic cytokines (VEGF, TGF-β, FGF), upregulates anti-inflammatory genes and growth hormone receptors, and promotes fibroblast proliferation essential for collagen formation.
Research applications
• Tendon and ligament healing: preclinical studies show improved biomechanical recovery, micro- and macroscopic, with increased load at rupture and collagen fibre formation
• Skeletal muscle: accelerated muscle healing after traumatic injury, reduced muscle proteolysis
• Skin and mucosa: modulatory effect on collagen, inflammatory cells and angiogenesis in skin wound models
• Gastrointestinal tract: cytoprotective activity and lesion repair
Biological properties studied
• Promotes angiogenesis and healing of various tissues (skin, mucosa, muscle, tendons, ligaments)
• Stimulates fibroblast proliferation and collagen formation
• Increases growth hormone receptor expression
• Anti-inflammatory and cytoprotective effects
• Potential synergy with TB-500 for tendon healing
• Protects endothelium and may reduce thrombotic complications
Preparation and storage
Reconstitute with bacteriostatic water; inject diluent along vial wall without shaking. Never mix one peptide with another in the same syringe. Reconstituted solution stored ~21 days refrigerated (2-8°C).
• Purity: ≥99% (HPLC)
• Presentation: Lyophilized powder 10 mg
• Storage: 2-8°C
• Recommended diluent: Bacteriostatic water (BA)
Research use only.
