Mechanism of action
Semaglutide is a GLP-1 (Glucagon-Like Peptide-1) analogue with extended half-life through structural modification and albumin binding. As a GLP-1R agonist, it exerts central effects (appetite regulation, satiety, energy centres) and peripheral effects: stimulation of glucose-dependent insulin secretion, glucagon inhibition, delayed gastric emptying. Research also explores its effects on lipid metabolism and adipose tissue distribution.
Research applications
• Glucose metabolism and glycemic control (HbA1c)
• Appetite regulation and satiety mechanisms
• Body composition and energy metabolism
• Adipose tissue inflammation and ectopic lipid deposition
Biological properties studied
• Central and peripheral GLP-1R agonism
• Improved insulin sensitivity
• Reduction of triglycerides and LDL cholesterol
• Extended half-life allowing weekly administration
• Purity: ≥99% (HPLC)
• Presentation: Lyophilized powder 20 mg
• Storage: 2-8°C
• Recommended diluent: Bacteriostatic water (BA)
• Reconstituted solution storage: ~21 days refrigerated (2-8°C)
Research use only.
