Mechanism of action
The HGH fragment 176-191 (AOD9604) is a lipolytic peptide derived from the C-terminal segment of growth hormone. Preclinical studies indicate indirect action via β3-adrenergic receptors (β3-AR): the peptide increases β3-AR expression in adipocytes, contributing to restoration of lipolytic sensitivity. Unlike full HGH, this fragment does not appear to significantly affect insulin sensitivity, making it a distinct research subject for lipid metabolism.
Research applications
• Mobilization of lipid reserves and fat metabolism
• Expression and regulation of β3-adrenergic receptors in adipocytes
• Research models on obesity and fat storage
Biological properties studied
• Lipolytic effect without notable insulinotropic action
• Potential to increase energy expenditure
• Selectivity of action compared to native HGH
• Purity: ≥99% (HPLC)
• Presentation: Lyophilized powder
• Storage: 2-8°C
Research use only.
